Biomedical Potential of Silver Nano Particles: An Overview
Keywords:
silver, nano, particles, toxic, drug-delivery, coatings, biomedical
Abstract
During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.
References
1. Nikaido, H (2009) Multidrug resistance in bacteria. Annual Review of Biochemistry, 78, pp. 119–146. doi.org/10.1146/annurev.biochem.78.082907.145923.
2. Talebian, S., et al. (2020) Nanotechnology-based disinfectants and sensors for SARS-CoV-2. Nature Nanotechnology, 15, pp. 618–621. doi.org/10.1038/s41565-020-0751-0.
3. Wang, L., et al. (2017) The antimicrobial activity of nanoparticles: Present situation and prospects for the future. International Journal of Nanomedicine, 12, pp. 1227–1249. doi.org/10.2147/IJN.S121956.
4. Varier, K. M., et al. (2019) Nanoparticles: Antimicrobial applications and its prospects. In: Advanced Nanostructured Materials for Environmental Remediation; Environmental Chemistry for a Sustainable World; Naushad, M., et al., Eds.; Springer: Cham, Switzerland; Volume 25, pp. 321–355.
5. Li, D., et al. (2020) Antibacterial therapeutic agents composed of functional biological molecules. Journal of Chemistry, 2020, p. 6578579. doi.org/10.1155/2020/6578579.
6. Hooper, D C (2001) Mechanisms of action of antimicrobials: Focus on fluoroquinolones. Clinical Infectious Diseases, 32, pp. S9–S15. doi.org/10.1086/319370.
7. Bazaka, K., et al. (2015) Antibacterial surfaces: Natural agents, mechanisms of action, and plasma surface modification. RSC Advances, 5, pp. 48739–48759. doi.org/10.1039/C4RA17244B.
8. Herman, A & Herman, A P (2014) Nanoparticles as antimicrobial agents: Their toxicity and mechanisms of action. Journal of Nanoscience and Nanotechnology, 14, pp. 946–957. doi.org/10.1166/jnn.2014.9054.
9. Almatar, M., et al. (2018) The role of nanoparticles in the inhibition of multidrug-resistant bacteria and biofilms. Current Drug Delivery, 15, pp. 470–484. doi.org/10.2174/1567201815666171207163504.
10. Gudikandula, K & Maringanti, S C (2016) Synthesis of silver nanoparticles by chemical and biological methods and their antimicrobial properties. Journal of Experimental Nanoscience, 11, pp. 714–721. doi.org/10.1080/17458080.2016.1139196.
11. Franci, G., et al. (2015) Silver Nanoparticles as Potential Antibacterial Agents. Molecules, 20, pp. 8856–8874. doi.org/10.3390/molecules20058856.
12. Siddiqi, K. S., et al. (2018) A review on biosynthesis of silver nanoparticles and their biocidal properties. Journal of Nanobiotechnology, 16, pp. 14–22. doi.org/10.1186/s12951-018-0334-5.
13. Yaqoob, A. A., et al. (2020) Silver nanoparticles: Various methods of synthesis, size affecting factors and their potential applications–a review. Applied Nanoscience, 10, pp. 1369–1378. doi.org/10.1007/s13204-020-01318-w.
14. Islam, A., et al. (2021) A critical review on silver nanoparticles: From synthesis and applications to its mitigation through low-cost adsorption by biochar. Journal of Environmental Management, 281, pp. 111918–111932. doi.org/10.1016/j.jenvman.2020.111918.
15. Syafiuddin, A., et al. (2017) A review of silver nanoparticles: Research trends, global consumption, synthesis, properties, and future challenges. Journal of the Chinese Chemical Society, 64, pp. 732–756. doi.org/10.1002/jccs.201700067.
16. Verma, A., et al. (2019) Green Nanotechnology: Advancement in phytoformulation research. Medicines, 6, pp. 39–49. doi.org/10.3390/medicines6010039.
17. Patra, J K & Baek, K-H (2014) Green nanobiotechnology: Factors affecting synthesis and characterization techniques. Journal of Nanomaterials, 2014, p. 417305. doi.org/10.1155/2014/417305.
18. Ansari, S. A., et al. (2012) Cost effective surface functionalization of silver nanoparticles for high yield immobilization of Aspergillus oryzae β-galactosidase and its application in lactose hydrolysis. Process Biochemistry, 47, pp. 2427–2433. doi.org/10.1016/j.procbio.2012.10.002.
19. Roy, A., et al. (2019) Green synthesis of silver nanoparticles: Biomolecule-nanoparticle organizations targeting antimicrobial activity. RSC Advances, 9, pp. 2673–2702. doi.org/10.1039/C8RA08982E.
20. Ahmad, S., et al. (2019) Green nanotechnology: A review on green synthesis of silver nanoparticles—An ecofriendly approach. International Journal of Nanomedicine, 14, pp. 5087–5107. doi.org/10.2147/IJN.S200254.
21. Javed, R., et al. (2020) Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: Recent trends and future prospects. Journal of Nanobiotechnology, 18, pp. 172–185. doi.org/10.1186/s12951-020-00704-4.
22. Verma, A & Mehata, M S (2016) Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity. Journal of Radiation Research and Applied Sciences, 9, pp. 109–115. doi.org/10.1016/j.jrras.2015.11.001.
23. Banerjee, P., et al. (2014) Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: Synthesis, characterization, antimicrobial property and toxicity analysis. Bioresources and Bioprocessing, 1, pp. 3–10. doi.org/10.1186/s40643-014-0003-y.
24. Saware, K & Venkataraman, A (2014) Biosynthesis and Characterization of Stable Silver Nanoparticles Using Ficus religiosa Leaf Extract: A Mechanism Perspective. Journal of Cluster Science, 25, pp. 1157–1171. doi.org/10.1007/s10876-014-0697-1.
25. Goudarzi, M., et al. (2016) Biosynthesis and characterization of silver nanoparticles prepared from two novel natural precursors by facile thermal decomposition methods. Scientific Reports, 6, pp. 32539–32549. doi.org/10.1038/srep32539.
26. Jadoun, S., et al. (2021) Green synthesis of nanoparticles using plant extracts: A review. Environmental Chemistry Letters, 19, pp. 355–374. doi.org/10.1007/s10311-020-01074-x.
27. Kim, M., et al. (2018) Widely used benzalkonium chloride disinfectants can promote antibiotic resistance. Applied and Environmental Microbiology, 84, pp. 17–25. doi.org/10.1128/AEM.01201-18.
28. Ahmed, S., et al. (2016) Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. Journal of Radiation Research and Applied Sciences, 9, pp. 1–7. doi.org/10.1016/j.jrras.2015.06.006.
29. Ansari, S. A., et al. (2017) Antibacterial activity of iron oxide nanoparticles synthesized by co-precipitation technology against Bacillus cereus and Klebsiella pneumoniae. Polish Journal of Chemical Technology, 19, pp. 110–115. doi.org/10.1515/pjct-2017-0076.
30. Khajav, R., et al. (2007) The antimicrobial effect of benzalkonium chloride on some pathogenic microbes observed on fibers of acrylic carpet. Pakistan Journal of Biological Sciences, 10, pp. 598–601. doi.org/10.3923/pjbs.2007.598.601.
31. Mazur, P., et al. (2020) Synergistic ROS-associated antimicrobial activity of silver nanoparticles and gentamicin against Staphylococcus epidermidis. International Journal of Nanomedicine, 15, pp. 3551–3562. doi.org/10.2147/IJN.S246484.
32. Krce, L., et al. (2020) Probing the mode of antibacterial action of silver nanoparticles synthesized by laser ablation in water: What fluorescence and AFM data tell us. Nanomaterials, 10, pp. 61–72. doi.org/10.3390/nano10061040.
33. Koschevic, M. T., et al. (2021) Antimicrobial activity of bleached cattail fibers (Typha domingensis) impregnated with silver nanoparticles and benzalkonium chloride. Journal of Applied Polymer Science, 138, pp. 55–67. doi.org/10.1002/app.50885.
2. Talebian, S., et al. (2020) Nanotechnology-based disinfectants and sensors for SARS-CoV-2. Nature Nanotechnology, 15, pp. 618–621. doi.org/10.1038/s41565-020-0751-0.
3. Wang, L., et al. (2017) The antimicrobial activity of nanoparticles: Present situation and prospects for the future. International Journal of Nanomedicine, 12, pp. 1227–1249. doi.org/10.2147/IJN.S121956.
4. Varier, K. M., et al. (2019) Nanoparticles: Antimicrobial applications and its prospects. In: Advanced Nanostructured Materials for Environmental Remediation; Environmental Chemistry for a Sustainable World; Naushad, M., et al., Eds.; Springer: Cham, Switzerland; Volume 25, pp. 321–355.
5. Li, D., et al. (2020) Antibacterial therapeutic agents composed of functional biological molecules. Journal of Chemistry, 2020, p. 6578579. doi.org/10.1155/2020/6578579.
6. Hooper, D C (2001) Mechanisms of action of antimicrobials: Focus on fluoroquinolones. Clinical Infectious Diseases, 32, pp. S9–S15. doi.org/10.1086/319370.
7. Bazaka, K., et al. (2015) Antibacterial surfaces: Natural agents, mechanisms of action, and plasma surface modification. RSC Advances, 5, pp. 48739–48759. doi.org/10.1039/C4RA17244B.
8. Herman, A & Herman, A P (2014) Nanoparticles as antimicrobial agents: Their toxicity and mechanisms of action. Journal of Nanoscience and Nanotechnology, 14, pp. 946–957. doi.org/10.1166/jnn.2014.9054.
9. Almatar, M., et al. (2018) The role of nanoparticles in the inhibition of multidrug-resistant bacteria and biofilms. Current Drug Delivery, 15, pp. 470–484. doi.org/10.2174/1567201815666171207163504.
10. Gudikandula, K & Maringanti, S C (2016) Synthesis of silver nanoparticles by chemical and biological methods and their antimicrobial properties. Journal of Experimental Nanoscience, 11, pp. 714–721. doi.org/10.1080/17458080.2016.1139196.
11. Franci, G., et al. (2015) Silver Nanoparticles as Potential Antibacterial Agents. Molecules, 20, pp. 8856–8874. doi.org/10.3390/molecules20058856.
12. Siddiqi, K. S., et al. (2018) A review on biosynthesis of silver nanoparticles and their biocidal properties. Journal of Nanobiotechnology, 16, pp. 14–22. doi.org/10.1186/s12951-018-0334-5.
13. Yaqoob, A. A., et al. (2020) Silver nanoparticles: Various methods of synthesis, size affecting factors and their potential applications–a review. Applied Nanoscience, 10, pp. 1369–1378. doi.org/10.1007/s13204-020-01318-w.
14. Islam, A., et al. (2021) A critical review on silver nanoparticles: From synthesis and applications to its mitigation through low-cost adsorption by biochar. Journal of Environmental Management, 281, pp. 111918–111932. doi.org/10.1016/j.jenvman.2020.111918.
15. Syafiuddin, A., et al. (2017) A review of silver nanoparticles: Research trends, global consumption, synthesis, properties, and future challenges. Journal of the Chinese Chemical Society, 64, pp. 732–756. doi.org/10.1002/jccs.201700067.
16. Verma, A., et al. (2019) Green Nanotechnology: Advancement in phytoformulation research. Medicines, 6, pp. 39–49. doi.org/10.3390/medicines6010039.
17. Patra, J K & Baek, K-H (2014) Green nanobiotechnology: Factors affecting synthesis and characterization techniques. Journal of Nanomaterials, 2014, p. 417305. doi.org/10.1155/2014/417305.
18. Ansari, S. A., et al. (2012) Cost effective surface functionalization of silver nanoparticles for high yield immobilization of Aspergillus oryzae β-galactosidase and its application in lactose hydrolysis. Process Biochemistry, 47, pp. 2427–2433. doi.org/10.1016/j.procbio.2012.10.002.
19. Roy, A., et al. (2019) Green synthesis of silver nanoparticles: Biomolecule-nanoparticle organizations targeting antimicrobial activity. RSC Advances, 9, pp. 2673–2702. doi.org/10.1039/C8RA08982E.
20. Ahmad, S., et al. (2019) Green nanotechnology: A review on green synthesis of silver nanoparticles—An ecofriendly approach. International Journal of Nanomedicine, 14, pp. 5087–5107. doi.org/10.2147/IJN.S200254.
21. Javed, R., et al. (2020) Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: Recent trends and future prospects. Journal of Nanobiotechnology, 18, pp. 172–185. doi.org/10.1186/s12951-020-00704-4.
22. Verma, A & Mehata, M S (2016) Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity. Journal of Radiation Research and Applied Sciences, 9, pp. 109–115. doi.org/10.1016/j.jrras.2015.11.001.
23. Banerjee, P., et al. (2014) Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: Synthesis, characterization, antimicrobial property and toxicity analysis. Bioresources and Bioprocessing, 1, pp. 3–10. doi.org/10.1186/s40643-014-0003-y.
24. Saware, K & Venkataraman, A (2014) Biosynthesis and Characterization of Stable Silver Nanoparticles Using Ficus religiosa Leaf Extract: A Mechanism Perspective. Journal of Cluster Science, 25, pp. 1157–1171. doi.org/10.1007/s10876-014-0697-1.
25. Goudarzi, M., et al. (2016) Biosynthesis and characterization of silver nanoparticles prepared from two novel natural precursors by facile thermal decomposition methods. Scientific Reports, 6, pp. 32539–32549. doi.org/10.1038/srep32539.
26. Jadoun, S., et al. (2021) Green synthesis of nanoparticles using plant extracts: A review. Environmental Chemistry Letters, 19, pp. 355–374. doi.org/10.1007/s10311-020-01074-x.
27. Kim, M., et al. (2018) Widely used benzalkonium chloride disinfectants can promote antibiotic resistance. Applied and Environmental Microbiology, 84, pp. 17–25. doi.org/10.1128/AEM.01201-18.
28. Ahmed, S., et al. (2016) Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. Journal of Radiation Research and Applied Sciences, 9, pp. 1–7. doi.org/10.1016/j.jrras.2015.06.006.
29. Ansari, S. A., et al. (2017) Antibacterial activity of iron oxide nanoparticles synthesized by co-precipitation technology against Bacillus cereus and Klebsiella pneumoniae. Polish Journal of Chemical Technology, 19, pp. 110–115. doi.org/10.1515/pjct-2017-0076.
30. Khajav, R., et al. (2007) The antimicrobial effect of benzalkonium chloride on some pathogenic microbes observed on fibers of acrylic carpet. Pakistan Journal of Biological Sciences, 10, pp. 598–601. doi.org/10.3923/pjbs.2007.598.601.
31. Mazur, P., et al. (2020) Synergistic ROS-associated antimicrobial activity of silver nanoparticles and gentamicin against Staphylococcus epidermidis. International Journal of Nanomedicine, 15, pp. 3551–3562. doi.org/10.2147/IJN.S246484.
32. Krce, L., et al. (2020) Probing the mode of antibacterial action of silver nanoparticles synthesized by laser ablation in water: What fluorescence and AFM data tell us. Nanomaterials, 10, pp. 61–72. doi.org/10.3390/nano10061040.
33. Koschevic, M. T., et al. (2021) Antimicrobial activity of bleached cattail fibers (Typha domingensis) impregnated with silver nanoparticles and benzalkonium chloride. Journal of Applied Polymer Science, 138, pp. 55–67. doi.org/10.1002/app.50885.
Published
2022-10-22
How to Cite
Gharu, C. P. (2022). Biomedical Potential of Silver Nano Particles: An Overview. International Journal on Orange Technologies, 4(10), 61-68. Retrieved from https://journals.researchparks.org/index.php/IJOT/article/view/3580
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