The level of lactate dehydrogenase and ferritin in the blood of Covid-19 patients compared to healthy people in Iraq
Abstract
60 samples were collected, 40 samples were for patients with CO-19 and 20 samples were for healthy control people. Tests were performed to know the patients people through the ADVIA Chemistry XPT System and an analysis was performed to find out the ratio of ferritin to patients based on I CHORMA. As for the LDH analysis, use the Cedex Bio Analyzer to find results were found that showed the great effect on ferritin and LDH, where the ratio of standard deviation to LDH to patients people was 441.5641 ± 234.80 and for control 185.08 ± 35.26 as for the analysis of ferritin, where the ratio of standard deviation was 853.92 ± 516.13 to patients people and for control 88.48 ± 59.44 And through the work of statistical analysis to know the effect of the CO-19 on the abnormal ratio, as the statistical analysis proved that there is a positive effect on ferritin and LDH to patients people and the control has a negative effect, and this explains the reason for the lack of the amount of iron present in the body is little if the person is a carrier of the disease
References
Lu, H., Stratton, C.W. and Tang, Y.W., 2020. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. Journal of medical virology, 92(4), pp.401-402.
Gorbalenya, A.E., Baker, S.C., Baric, R., Groot, R.J.D., Drosten, C., Gulyaeva, A.A., Haagmans, B.L., Lauber, C., Leontovich, A.M., Neuman, B.W. and Penzar, D., 2020. Severe acute respiratory syndrome-related CO-19virus: The species and its viruses–a statement of the CO-19virus Study Group.
Hui, D.S., Azhar, E.I., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Mchugh, T.D., Memish, Z.A., Drosten, C. and Zumla, A., 2020. The continuing 2019-nCoV epidemic threat of novel CO-19viruses to global health—The latest 2019 novel CO-19virus outbreak in Wuhan, China. International Journal of Infectious Diseases, 91, pp.264-266.
Burki, T.K., 2020. CO-19virus in China. The Lancet. Respiratory Medicine, 8(3), p.238.
World Health Organization, 2020. CO-19virus disease 2019 (COVID-19): situation report, 82.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X. and Cheng, Z., 2020. Clinical features of patients infected with 2019 novel CO-19virus in Wuhan, China. The lancet, 395(10223), pp.497-506.
Burrell, C.J., Howard, C.R. and Murphy, F.A., 2016. Fenner and White's Medical Virology. Academic Press.
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K.S., Lau, E.H., Wong, J.Y. and Xing, X., 2020. Early transmission dynamics in Wuhan, China, of novel CO-19virus–infected pneumonia. New England Journal of Medicine.
Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J. and Hsueh, P.R., 2020. Severe acute respiratory syndrome CO-19virus 2 (SARS-CoV-2) and CO-19 virus disease-2019 (COVID-19): the epidemic and the challenges. International journal of antimicrobial agents, p.105924.
Carlos, W.G., Dela, C.C., Cao, B., Pasnick, S. and Jamil, S., 2020. Novel Wuhan (2019-nCoV) CO-19virus. American journal of respiratory and critical care medicine, 201(4), p.P7.
Chowell, G., Abdirizak, F., Lee, S., Lee, J., Jung, E., Nishiura, H. and Viboud, C., 2015. Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study. BMC medicine, 13(1), pp.1-12.
Adhikari, S.P., Meng, S., Wu, Y.J., Mao, Y.P., Ye, R.X., Wang, Q.Z., Sun, C., Sylvia, S., Rozelle, S., Raat, H. and Zhou, H., 2020. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of CO-19virus disease (COVID-19) during the early outbreak period: a scoping review. Infectious diseases of poverty, 9(1), pp.1-12.
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K.S., Lau, E.H., Wong, J.Y. and Xing, X., 2020. Early transmission dynamics in Wuhan, China, of novel CO-19virus–infected pneumonia. New England Journal of Medicine.
Velavan, T.P. and Meyer, C.G., 2020. The COVID‐19 epidemic. Tropical medicine & international health, 25(3), p.278.
Rothan, H.A. and Byrareddy, S.N., 2020. The epidemiology and pathogenesis of CO-19virus disease (COVID-19) outbreak. Journal of autoimmunity, p.102433.
Wang, W., Tang, J. and Wei, F., 2020. Updated understanding of the outbreak of 2019 novel CO-19virus (2019‐nCoV) in Wuhan, China. Journal of medical virology, 92(4), pp.441-447.
Ronni, T., Matikainen, S., Sareneva, T., Melen, K., Pirhonen, J., Keskinen, P. and Julkunen, I., 1997. Regulation of IFN-alpha/beta, MxA, 2', 5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells. The Journal of Immunology, 158(5), pp.2363-2374.
Winkle, D.C., Clague, A.E. and Gardiner, R.A., 1988. ELNATED LACTATE DEHYDROGENASE ISOENZYME I AS A TUMOUR MARKER IN PATIENTS WITH GERM CELL TESTICULAR TUMOURS. Australian and New Zealand Journal of Surgery, 58(9), pp.737-741.
Schneider, R.J., Seibert, K., Passe, S., Little, C., Gee, T., Lee III, B.J., Miké, V. and Young, C.W., 1980. Prognostic significance of serum lactate dehydrogenase in malignant lymphoma. Cancer, 46(1), pp.139-143.
Rambotti, P. and Davis, S., 1981. Lactic dehydrogenase in normal and leukemia lymphocyte subpopulations: evidence for the presence of abnormal T cells and B cells in chronic lymphocytic leukemia.
Pan, L., Beverley, P.C., Bobrow, L.G., Swallow, D.M. and Isaacson, P.G., 1989. Production of monoclonal antibodies to lactate dehydrogenase (LDH) isoenzymes for immunohistochemical study on fixed tissue section. The Histochemical Journal, 21(11), pp.638-644.
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